Cutting Out the Middleman

Uploaded: 21 Jul 2012

I don’t know about you but I always like to tackle the hard stuff first. So here goes.

While doing all this new research, I came across a research paper entitled “Optimal Control of Innate Immune Response,” authored by Robert F. Stengel, Raffaele Ghigliazza, Nilesh Kulkarni, and Olivier Laplace, of the School of Engineering and Applied Science, Princeton University. I hate to do this to you, but please read the abstract:

Treatment of a pathogenic disease process is interpreted as the optimal control of a dynamic system. Evolution of the disease is characterized by a non-linear, fourth-order ordinary differential equation that describes concentrations of pathogens, plasma cells, and antibodies, as well as a numerical indication of patient health. Without control, the dynamic model evidences sub-clinical or clinical decay, chronic stabilization, or unrestrained lethal growth of the pathogen, depending on the initial conditions for the infection. The dynamic equations are controlled by therapeutic agents that affect the rate of change of system variables. Control histories that minimize a quadratic cost function are generated by numerical optimization over a fixed time interval, given otherwise lethal initial conditions. Tradeoffs between cost function weighting of pathogens, organ health, and use of therapeutics are evaluated. Optimal control solutions that defeat the pathogen and preserve organ health are demonstrated for four different approaches to therapy. It is shown that control theory can point the way toward new protocols for treatment and remediation of human diseases. Copyright # 2002 John Wiley & Sons, Ltd.

KEY WORDS: optimal control; biological modelling; bioinformatics; optimization

The paper was written in 2000 and revised in 2002.

It certainly seems like a worthy project, mathematically modeling the human immune system response to pathogens by taking all variables into account and reducing treatment options to equations for optimal outcomes.

I think you could say without fear of contradiction that such information would be very beneficial for mankind.

However, it’s ONLY beneficial in the right hands.

In the wrong hands, once you know the input variables to produce a good outcome in patients, you also know how to alter the equations to most efficiently produce lethal outcomes.

Knowledge is power.

This research was jointly funded by the Alfred P. Sloan Foundation and the Burroughs-Wellcome Fund for Biological Dynamics.

Let’s take a look at some areas of particular interest to these two grant-making bodies.

The Alfred P. Sloan Foundation:

Alfred P. Sloan was president, chairman, and CEO of General Motors from the 1920s until the 1950s. He built GM into the largest corporation on Earth. GM in America, as corporate parent of Adam Opel AG, its German subsidiary, is remembered today for being cozy with Nazism and for profiting from German rearmament - right up to the attack on Pearl Harbor, when Germany (through its Axis with Japan) at last became a "real enemy.”

In 2000 the Sloan Foundation initiated a national program to prevent bioterrorism that has evolved to address general terrorism preparedness, and has made 40 grants totaling over $17 million.

1. Synthetic Biology: identify the risks associated with research in and applications of synthetic biology and to assess the ethical, regulatory, and public policy implications of these risks. A grant to The Hastings Center aims to engage the ethical community to identify and articulate ethical issues. A Sloan-funded project at the J. Craig Venter Institute is educating the scientific community about societal concerns and educating the policy and journalism communities about the underlying science. A grant to the Woodrow Wilson International Center to identify risks, evaluate the adequacy of existing regulatory mechanisms, and educate policy makers and the public through events and its website.

Publications, Projects & Events include: “Trends in American & European Press Coverage of Synthetic Biology”; “Nanotechnology, Synthetic Biology, and Biofuels”; “Synthetic Biology on the Nanofrontier?”; “Popping the Cork on Synthetic Biology”; “Synthetic Biology on the Rise,” and “How Do You Stop a Synthetic-Biology Disaster?” Full list here.

2. Microbiology of the Built Environment: we average 23 hours a day indoors where we breathe and come in contact with trillions of microorganisms - tiny life forms invisible to the naked eye. Human beings are composed of 10 times as many microbial cells as human cells and we are constantly shedding, acquiring and sharing microbes.

Active Sloan Grants: as of 29 March 2012, there were 29 grants active in this interest area, including Airborne microbiota, Bacterial and fungal diversity in 1,000 US homes, The microbiology of the drinking water system, Microbiomes of homes across cultures, Microbial communities of workspaces and retail stores, Microbial genomics in the indoor environment, and of Outdoor and indoor air in New York City. The full list is here.

3. Barcode of Life: create a library of short DNA sequences (barcodes) to identify animal and plant species reliably and inexpensively.

Publications include: “Wolbachia and DNA Barcoding Insects: Patterns, Potential, and Problems”; “A new feather mite species of the genus Proctophyllodes Robin, 1877 (Astigmata: Proctophyllodidae) from the Long-tailed Tit Aegithalos caudatus (Passeriformes: Aegithalidae) - morphological description with DNA barcode data”; “Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for Fungi,” and “DNA barcoding of parasitic nematodes: Is it kosher?”

4. Deep Carbon Observatory: aims to revolutionize our understanding of the carbon deep in the Earth, including its connections to the origins of life and to the origins, distribution, and abundance of fossil fuels, through a multidisciplinary international network that develops and applies new instruments, takes observations, and performs analyses.

Research highlights include: “Mercury Mineral Evolution”; “Ancient Microbial Communities Deep in Seafloor Clays”; “Dark Energy Biosphere Research, Past and Future”;”Stability of Polymeric CO2 in the Earth’s Mantle”; “Underworld Nematodes Expand Known Biosphere”; “Directed Evolution Under Pressure, and Microbiology of the Deep Oceanic Crust.”

5. Sloan Digital Sky Survey - Mapping the Universe: expanding our understanding of the evolution and structure of the universe by providing the largest uniform, detailed archive of objects in the skies that has ever existed. In cooperation with the Astrophysical Research Consortium, the Foundation has helped build and operate a specially designed telescope to observe and archive galaxies, quasars and other cosmological phenomena. Data collected through the SDSS is providing an increasingly detailed picture of the universe, including data bearing on the curvature of the universe itself, on the existence of dark energy, and on the features of the Milky Way.

Publications: too many to list here.

The Burroughs-Wellcome Fund:

Originally, this was the US extension of the Wellcome Trust, the world’s largest grant aid body devoted to biomedical science. In 1993, the Burroughs-Wellcome Fund became independent with the gifting of $400 million from its parent trust. It is also no longer affiliated with its founding pharmaceutical corporation which was eventually to be absorbed into the giant GlaxoSmithKline.

In July, 2012 this British multinational pleaded guilty to criminal charges of fraud and was fined $3 billion - the largest fine in history - for actively promoting its top-selling antidepressants for unapproved uses and failing to report safety data on its diabetic drug Avandia. There were also fines for improper marketing of six other drugs.

Besides biomedical sciences, this body’s areas of interest include Infectious Diseases, Population Sciences, Reproductive Sciences, and Science Education. The number of grants made each year is mind-boggling. Here’s just a few of the grant aided research programs funded from 2007:

Genetics of transcription in budding yeast; Gene duplication and the evolution of function in regulatory networks; Single-molecule study of bacteriophage DNA packaging and mitochondrial protein import; Natural and vaccine-induced immunity and spatiotemporal dynamics of epidemic dengue; Tracking neural programs for song; Combinatorial and computational approach to deciphering the biological information encoded by single-stranded nucleotide sequences; Building a mechanistic model of the structure and function of a kinetochore-microtubule attachment (these play a vital role in cell mitosis and meiosis); Understanding the mechanisms of sensitivity in gene expression; Dynamic structural biology of ion channel proteins: an ultra-stable atomic force microscope study (ion channels control the electrical properties of cells); Composition analysis of the influenza virus pre-envelope by multiple isotope imaging mass spectrometry (MIMS); High-resolution analysis of tumour genome architectures; Active sensing in natural and robotic organisms; and Molecular mechanism of dynein in vitro and in living cells (this is a motor protein which converts chemical energy to movement and is vital for cell survival).

In 2000-2001, three projects on human parasitic worms were funded.

If you wish to research grants made in other years, the Fund’s annual reports for 2001-2011 are available here.

Please understand that I’m not suggesting any improprieties by these two bodies, merely noting some areas of research that are actively supported by such private organisations. But please remember that knowledge gained for good may also be used for evil - if it gets into the wrong hands.

Once again, knowledge is power.

Link: “Optimal Control of Innate Immune Response_ - downloadable PDF of the Princeton University research paper.

Link: A New York Times feature article on J. Craig Venter - “In the menagerie of Craig Venter’s imagination, tiny bugs will save the world. They will be custom bugs, designer bugs - bugs that only Venter can create. He will mix them up in his private laboratory from bits and pieces of DNA, and then he will release them into the air and the water, into smokestacks and oil spills, hospitals and factories and your house.”

Link: Website of the J. Craig Venter Institute.

Link: The Woodrow Wilson International Center (now called simply The Wilson Center). Issues studied: Cold War, Conflict Resolution and Peacebuilding, Democracy, Disaster Management, Economics and Globalisation, Education, Energy, Environment, Food and Agriculture, Gender, Global Health, Global Governance, Governance, History, Human Rights, International Development, Migration, Population, Science and Technology, Security and Defence, Society and Culture, Urban Studies, and US Politics. Its remit - the world.

The relevance of all of this will become apparent in the next section, “Our Future.”

Mind Control

I’m sure most of you have heard of Pavlov’s Dog. However, let me just refresh your memory.

Pavlov was a Russian physiologist who wanted to study rates of salivation in dogs. So he could do this easily, he exposed the animals’ salivary glands through surgery.

In 1901, he noticed that when delivering food to his experimental subjects, they instantly started to salivate. As an experiment, he started to ring a bell each time he delivered dinner. After doing this a number of times, he found that simply ringing the bell - without any food - induced salivation in the dogs.

He called this “the conditioned reflex,” and it was the chief progenitor of the psychological barbarity known as “behaviourism.”

According to Wikipedia, this holds “that behaviors as such can be described scientifically without recourse either to internal physiological events or to hypothetical constructs such as the mind.”

You may well ask, does it work on humans?

Oh, boy, does it ever!

Read this abstract of a 2002 research paper and weep:

“Behavioral conditioned immunosuppression has been described in rodents as the most impressive demonstration of brain-to-immune system interaction. To analyze whether behavioral conditioned immunosuppression is possible in humans, healthy subjects in this double-blind, placebo-controlled study were conditioned in four sessions over 3 consecutive days, receiving the immunosuppressive drug cyclosporin A as an unconditioned stimulus paired with a distinctively flavored drink (conditioned stimulus) each 12 h. In the next week, re-exposure to the conditioned stimulus (drink), but now paired with placebo capsules, induced a suppression of immune functions as analyzed by the IL-2 and IFN-γ mRNA expression, intracellular production, and in vitro release of IL-2 and IFN-γ, as well as lymphocyte proliferation. These data demonstrate for the first time that immunosuppression can be behaviorally conditioned in humans.

In other words, the pairing of an unconditioned physiological stimulus with a conditioned SENSORY stimulus even for a short period can trick your brain into reacting to the former even after it has been withdrawn.

This means that an outside agency can gain control over your immune system without your knowledge or consent.

Link: “Behavioral conditioning of immunosuppression is possible in humans” - Marion E. Goebel, Almuth E. Trebst, Jan Steiner, Yu F. Xie, Michael S. Exton, Stilla Frede, Ali E. Canbay, Martin C. Michel, Uwe Heeman, and Manfred Schedlowski, Dept. of Medical Psychology, University of Essen. Published in the Journal of the Federation of American Societies for Experimental Biology.

Your five senses are wide open doorways into your mind.


Dig out your favourite fiction writer and find a fairly long descriptive passage in one of her works. Go through it and note how, even though she may be describing something visual, she brings in many other senses as well - so, in a forest scene, for example, she describes the visual scene, but may also refer to the scent of wood, leaves, or vegetation, the texture of tree bark or lichens, or the feel of moss underfoot, the sound of birdsong or leaves rustling in the breeze, the taste of fresh air in the back of the throat.

This is what good writers do - they engage all five senses of the reader. Poor writers don’t know how do this - and this is why you’ll quickly toss a bad book aside.

There is also that which may be inferred by the audience but is not specifically stated. But how such subtext is created in your mind would take up a whole page by itself, so I’ll leave you to research it yourself if you’re interested.

Advertising is - or should be - another form of creative writing. In fact, the people who think up ads are called “creatives.” As an ex-copywriter, I used these tricks all the time whenever I made a commercial. All effective advertising is based on quickly connecting to the viewer’ emotions.

Animals have just two emotions. And, at root, so do we humans. They are:

Love. And fear.

Every other human emotion can be distilled down to one or the other.

The basic formula for most advertising is contained in the acronym AIDA.

1. Attention: the opening three-to-five seconds must grab you so you’ll pay attention to the message.
  • Sensory appeal to: sight (colour, shape, movement), sound (intensity, inflection, music).
  • Emotion: love, fear.
2. Interest: the message must engage your interest.
  • Sensory appeal to: sight, sound, taste (sweet, sour, salt, bitter), smell (fresh, rotten, pleasant, acrid), touch (texture, temperature).
  • Emotion: love, fear.
3. Desire: the message must provoke your desire.
  • Sensory appeal to: sight, sound, taste, smell, touch.
  • Emotion: love, fear.
4. Action: the message must cause you to act.
  • Sensory appeal to: sight, sound, taste, smell, touch.
  • Emotion: love, fear.

The sensory appeals and emotions I choose to elicit depend on what I’m selling. For instance, a commercial for life insurance or medication will generally hook you with love (for those who depend on you or self-regard) and leave you with fear (so you will act on the message). An ad for antiperspirant may start with fear (of rejection, not “fitting in,” failure) and leave you with love (self-regard, peer group acceptance, and conformity).

Words, sounds, images, smells, tastes, feels - all of these carry piggy-backed triggers and emotional associations that may not be apparent to your conscious mind. But your subconscious mind will absorb and act upon them.

The prestigious side of advertising - selling a brand rather than simply just a product - uses a more advanced technique.

This is an area we’ll return to on a later page but for now here it is:

Besides action, the most powerful human response possible is feeling. Feeling is not emotion - it is the product of emotion combined with thought.

The thought comes from your mind, the emotion comes from your gut and solar plexus, and when thought is imbued with emotion, a feeling is produced.

And feeling emanates only from your heart.

Techniques like these are routinely used in advertising - and in entertainment and news coverage. Next time you watch a commercial, or listen to one on radio, or read one in print or on outdoor media, see if you deconstruct it in this way. The best ads are those that cleverly hide the sticks and carrots from your conscious view.

But it’s not just advertisers that want control of your mind. Cults do, too. So do all institutions that depend on your participation or acquiescence for their continued existence because they know that while an appeal to the logical mind may fail, an appeal to emotions coupled with implanted thought - and thus, the feeling - bypasses the conscious mind’s filters and goes straight to the subconscious.

Some 95-98% of people are completely unaware that mind control is an everyday reality in their lives.

“Even as he dances to the tune of the elite managers of human behavior, the modern man scoffs with a great derision at the idea of the existence and operation of a technology of mass mind control emanating from media and government. Modern man is much too smart to believe anything as superstitious as that! Modern man is the ideal hypnotic subject: puffed up on the idea that he is the crown of creation, he vehemently denies the power of the hypnotist’s control over him as his head bobs up and down on a string” - Michael A. Hoffman II, Secret Societies and Psychological Warfare.

(The remainder of this page has been deleted due to startling new information that’s come to light. This concerns subliminal programming in children’s movies and TV and two horrific mind control systems used by intelligence agency black ops - MK-Ultra and Monarch Programming. Once I’ve uploaded this entire update, I’ll complete and verify the research and re-upload this page).

Nevertheless, the evidence is very clear - your immune system is wide open to sources of direct input.
Read on to continue the story...